By Dennis F. Kohn, Sally K. Wixson, William J. White, G. John Benson
Anesthesia and Analgesia in Laboratory Animals focuses fullyyt at the specified anesthetic, analgesic, and postoperative care requisites linked to experimental surgical procedure. subsidized by way of the yankee collage of Laboratory Animal drugs, this informative paintings offers the reader with brokers, equipment, and strategies for anesthesia and analgesia that make sure humane and profitable procedural results. Key gains * makes a speciality of a wide selection of animal species utilized in study * presents a accomplished evaluation of the pharmacology of anesthetics and analgesics * comprises tracking of analgesia and anesthesia * Organizes subject matters via species for brokers and techniques of offering anesthesia, analgesia, and post-op care to animals * No different American textual content is dedicated totally to this subject
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Extra info for Anesthesia and Analgesia in Laboratory Animals
The primary objective of inhalant anesthesia is to produce a constant and sufficient partial pressure of the anesthetic in the brain to produce analgesia and unconsciousness. The vesselrich group of tissues, which includes the brain, receives approximately 75% of the cardiac output (Eger, 1964). Because of the large blood flow to this small compartment, equilibration rapidly occurs between the anesthetic concentration in the blood and the brain. Because nitrous oxide, desflurane, and sevoflurane have exceptionally low blood/gas solubilities, they are associated with especially rapid uptake and elimination (Eger, 1992; Jones, 1990).
Anesthesiol. Clin. 26, 176-181. , and Richards, C. D. (1991). Cellular mechanisms in general anaesthesia. Br. J. Anaesth. 66, 116-128. Priano, L. , and Marrone, B. (1989). Effect of anesthetic induction agents on cardiovascular neuroregulation in dogs. Anesth. Analg. 68, 344-349. Reeves, J. , Fragen, R. , Vinik, H. , and Greenblatt, D. J. (1985). Midazolam: Pharmacology and uses. Anesthesiology 62, 310-324. Reynolds, J. E. E, ed. (1989). " Pharmaceutical Press, London. , Miller, K. , and Roth, S.
Measurements of anesthetic concentrations at the end of expiration provide the most accurate estimation of the anesthetic concentration in the blood leaving the lungs. A noxious supramaximal stimulus is then applied to the animal and the animal is observed for gross purposeful movement or the absence of movement. During MAC determinations, stretching, increased ventilation, or spontaneous movement, which is an elicited reflex, is not considered evidence of movement. , 1980). If no response is observed, the alveolar concentration is reduced by 20% of the previous setting, 15 min is allowed to elapse for equilibration, and the stimulus is repeated.
Anesthesia and Analgesia in Laboratory Animals by Dennis F. Kohn, Sally K. Wixson, William J. White, G. John Benson